Browns defensive end Desmond Bryant was taken to the Cleveland Clinic in the third quarter after experiencing shortness of breath. Last year with Oakland, Bryant had to be hospitalized during a game with an irregular heartbeat, but returned to play the next week
With Buffalo leading 24-17, Weeden found a streaking Gordon down the left sideline and the wide receiver made a juggling catch with 5:53 left in the quarter.
It was Weeden's first TD pass since Week 1, and his first scoring connection this season with Gordon, who was suspended for the first two games.
Weeden started slowly but finished 13 of 24 for 197 yards, and was sacked five times.
Weeden missed Cleveland's past two games, and although he had been cleared to play this week, Browns coach Rob Chudzinski chose to stay with Hoyer, who had beaten Minnesota and Cincinnati the past two weeks, throwing clinching TDs late in both wins.
But Hoyer, the hometown kid with Browns roots having a storybook start in his hometown, didn't make it out of the first quarter.
With the Browns trailing 7-0, Hoyer took off on an 11-yard run and was sliding after picking up the first down when he was hit from the side by rookie linebacker Kiko Alonso.
Both of Hoyer's knees were bent awkwardly on the hit in front of Cleveland's bench, and several players and coaches yelled for a penalty to be called on Alonso. Hoyer stayed on the ground for several moments before he was assisted to a trainer's table. After he was examined, Hoyer limped unassisted to the locker room for tests and treatment.
Hoyer was attempting to become the first quarterback in team history to win his first three starts, now he may not get back on the field this season.
At halftime, Chudzinski told NFL Network he feared Hoyer has torn ligaments. A Browns spokesman confirmed the coach's comment, but did not verify Hoyer will undergo an MRI on Friday.
Manuel got hurt at the end of a 14-yard when he was hammered near the sideline by Browns safety Tashaun Gipson. Manuel walked off the field attempted to get his knee loose on the sideline by jogging and riding a stationary bike. But after having his knee examined, he jogged to the locker room with two trainers.
Tuel went just 8 of 20 for 80 yards.