The Sabres gave up a goal on the first shot for the second straight game.
Evander Kane extended his point streak to four games (a goal and two assists) by outmuscling two Sabres defenders and digging out the puck at the end boards. He then made a no-look pass into the middle to a wide-open Little, who snapped it past Ryan Miller 1 minute in.
That was reminiscent of the Penguins scoring on their first two shots in the first 87 seconds of a 4-3 win at Buffalo on Sunday.
Miller was otherwise sharp in finishing with 26 saves, and bailing out his teammates on several defensive miscues. Miller foiled Jim Slater trying to beat him through the legs on a breakaway with 2 minutes left in the opening period. He also made a diving poke check to stop Kane on a partial short-handed breakaway with 20 seconds left in the first period.
The Jets' lead held up through the opening period, marking only the second time this season Winnipeg has led after 20 minutes.
What also has become familiar in Buffalo is the Sabres getting excessively booed by their fans throughout much of the second period. They were booed during a 1-minute stretch in which they were bottled up in their own zone. And they earned a Bronx cheer when they finally crossed the Jets blue line.
The real cheers finally came when Pominville scored on a 2-on-1 break with 22 seconds left in the second period. Breaking up the left wing following a Jets giveaway inside the Sabres blue line, Pominville snapped a shot from the left circle that beat Pavelec just inside the far post.
NOTES: Sabres D Jordan Leopold became the latest to land in coach Lindy Ruff's doghouse, becoming a healthy scratch for the first time this season. ... Jets penalty killers went 3 for 3 after entering the game having allowed an NHL-worst 15 goals on 44 power-play chances. The Jets are 4-0-1 when they don't give up a power-play goal. ... Pominville's goal snapped a six-game point drought that matched the longest of his career, according to STATS. ... The Jets have not lost four in a row in regulation since a four-game skid from Jan. 21-31, 2009, when they were the Atlanta Thrashers.