With Manuel nursing his injury, and after Kevin Kolb left the Redskins game with concussion-like symptoms in the first quarter, the only Bills quarterback left was undrafted rookie Tuel, who completed 10 of 17 passes for just 63 yards and looked like an undrafted rookie.
Forget Plan B. Time for Plan C. Or D. Or E.
"It is a concern," Marrone said. "I'm not going to sit here and say everything's fine and dandy."
The Bills have other issues, particularly in the secondary. Safety Da'Norris Searcy suffered a head injury, and cornerback Stephon Gilmore left with an injured wrist.
Marrone didn't have an update on either player. Fortunately, he's getting back two-time Pro Bowl safety Jairus Byrd, who was on the sidelines Saturday after rejoining the team following a contentious offseason.
Byrd might be a bit grumpy, though: He was hoping for a huge multiyear contract as a free agent this year, but in the end he had no choice but to sign a one-year deal after Buffalo designated him as a franchise player.